London chasers Tomas Berdych and Stanislas Wawrinka both crashed out of the Basel event in Tuesday in first round defeats.
Berdych, who stands sixth in the London Race (top nine with Murray out will qualify), remains in good shape after losing a matchpoint in a final set breaker loss to Ivo Karlovic.
But in the eighth spot is Wawrinka who really hurt his chances getting stunned by Edouard Roger-Vasselin 6-4, 6-3 on his home soil.
Kei Nishikori and Marcos Baghdatis were also winners on the day.
On Wednesday, after a strong first round win over Adrian Mannarino, Roger Federer returns to face Denis Istomin. Federer is currently 7th position and with big points in Paris looming next week, is not a sure bet to make London.
Grigor Dimitrov, who Federer could meet in the quarters, plays Radek Stepanek. Top seed Juan Martin Del Potro and Richard Gasquet are also in action.
Upsets also hit Valencia as local favorite Fernando Verdasco and Gilles Simon both went down. Tomorrow in a good line-up, Ernests Gulbis meets John Isner, David Ferrer faces Gael Monfils and Tommy Haas draws Philipp Kohlschreiber in an all-German affair.
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