Roddick, Isner Lead Americans, Bryan Brothers Beat Nadal at Indian Wells

Roddick dispatched of No. 31 seed Nicolas Kiefer 6-4, 7-6(4), while Isner upset No. 24 seed and former No. 1 Marat Safin 6-4, 6-4 in a serving display.

"It's got to be one of my better wins," Isner said. "He's not No. 1 in the world like he used to be, but still he's one of the greatest players ever...With these conditions, the air is pretty thin. The court is slow, but (the ball) bounces really high, which is my type of court."

Roddick and Isner are back on court today, with Roddick facing No. 12 David Ferrer, who outlasted France's Jeremy Chardy in three sets Tuesday, and Isner against No. 6 Juan Martin Del Potro, who won a draining three-setter over No. 30 seed Jurgen Melzer 7-6 in the third.

World No. 1 Rafael Nadal and No. 14 seed David Nalbandian set up a meeting today with Tuesday straight-set wins over No. 26 Dmitry Tursunov and Viktor Troicki respectively.

World No. 3 Novak Djokovic turned back former world No. 2 Tommy Haas 6-2, 7-6(1), and today meets No. 16-seeded Swiss Stan Wawrinka, who handed unseeded Sam Querrey a heartbreaker, saving two match points against the American in a 2-6, 7-5, 7-6(8) win.

Bob and Mike Bryan, top seeded in the doubles, advanced with a 6-4, 6-3 win over the Spanish squad of world No. 1 Nadal and Marc Lopez.

"I like to play doubles, but normally it's tough to combine doubles and singles," Nadal said. "But here it's two weeks tournament and you have more days off during the tournament, and especially to practice a little bit. And at the same time, I play with a good friend. I enjoy playing with a good friend of mine."